Coffee Drinkers Rejoice!

In one of their periodic quizzes to test clinician knowledge, Medscape reinterates that caffeine consumption is associated with a LOWER risk of development of Parkinson’s Disease.

A relationship between increased caffeine intake and lower risk for Parkinson’s disease has been repeatedly confirmed. A more recent study that specifically focused on the effects of caffeine in individuals with a mutation in the leucine-rich repeat kinase 2 (LRRK2) gene found that that group in particular may benefit from caffeine-related therapies.

Windle, Medscape

Yes, caffeine as a “therapy.”

Further, coffee consumption benefits patients with chronic liver disease.

A systematic review found that patients with chronic liver disease who consume coffee have a decreased risk for progression to cirrhosis, a lower mortality rate, and a lower rate of hepatocellular carcinoma development.


A combination of acetylsalicylic acid (aspirin), acetaminophen, and caffeine is approved in the US as a safe and effective treatment for migraine headaches. (However, in some countries, acetylsalicylic acid is limited to veterinary use.)

However, one can overdo caffeine. There is a special caution for smokers who decide to kick that happen. Cessation may increase the caffeine concentration in the body. A smoker who is borderline for caffeine toxicity may have problems immediately after quitting tobacco. Problems with overdoing caffeine are more likely due to consumption of dietary supplements and energy drinks than coffee.(2,3)

One teaspoon of powdered caffeine is equivalent to 28 cups of coffee!(4)

It really sounds like its best to take your caffeine the old fashioned way!


  1. Mary L. Windle, PharmD, “Fast Five Quiz: Caffeine Clinical Concerns”, Feb. 12, 2021,


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