Covid-19: New Findings

Two separate reports link Covid-19 with kidney damage, and severity of kidney damage to likelihood of death from Covid-19.

The findings:

1, Researchers at the University of Michigan report that “patients with COVID-19 experience elevated levels of soluble urokinase receptor (suPAR), an immune-derived pathogenic protein that is strongly predictive of kidney injury.”(1,2)

2. Data from Tongji hospital in Wuhan, China, indicates that kidney damage increases the likelihood of death during hospital stays for coronavirus victims.(3,4,5)

That leaves the interesting question: Do those who are infected but not hospitalized also sustain kidney damage? What impact might that have on long-term health? Unfortunately, only time will tell.

Sources:

  1. Tariq U. Azam, Husam R. Shadid, Pennelope Blakely, Patrick O’Hayer, Hanna Berlin, Michael Pan, Peiyao Zhao, Lili Zhao, Subramaniam Pennathur, Rodica Pop-Busui, Izzet Altintas, Jens Tingleff, Marius A. Stauning, Ove Andersen, Maria-Evangelia Adami, Nicky Solomonidi, Maria Tsilika, Pinkus Tober-Lau, Eleni Arnaoutoglou, Verena Keitel, Frank Tacke, Athanasios Chalkias, Sven H. Loosen, Evangelos J. Giamarellos-Bourboulis, Jesper Eugen-Olsen, Jochen Reiser, Salim S. Hayek. Soluble Urokinase Receptor (SuPAR) in COVID-19–Related AKI. Journal of the American Society of Nephrology, 2020; ASN.2020060829 DOI: 10.1681/ASN.2020060829
  2. Rush University Medical Center. “Patients with COVID-19 may have higher risk of kidney injury: Levels of protein called suPAR linked to acute kidney injury in patients studied.” ScienceDaily. ScienceDaily, 22 September 2020. www.sciencedaily.com/releases/2020/09/200922172612.htm.
  3. Yichun Cheng, Ran Luo, Xu Wang, Kun Wang, Nanhui Zhang, Meng Zhang, Zhixiang Wang, Lei Dong, Junhua Li, Rui Zeng, Ying Yao, Shuwang Ge, Gang Xu. The Incidence, Risk Factors, and Prognosis of Acute Kidney Injury in Adult Patients with Coronavirus Disease 2019. Clinical Journal of the American Society of Nephrology, 2020; CJN.04650420 DOI: 10.2215/CJN.04650420
  4. Edward D. Siew, Bethany C. Birkelo. COVID-19–Associated Acute Kidney Injury. Clinical Journal of the American Society of Nephrology, 2020; CJN.13600820 DOI: 10.2215/CJN.13600820
  5. American Society of Nephrology. “Kidney damage from COVID-19 linked to higher risk of in-hospital death.” ScienceDaily. ScienceDaily, 22 September 2020. www.sciencedaily.com/releases/2020/09/200922172630.htm.

4 comments

  1. That’s really interesting, thanks for sharing. One of the meds I take for BP (ACE-inhibitor iirc) can also impact kidney function. I wonder if anybody spotted a link between COVID and high BP?

    Like

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