Weight loss and remission in Type 2 Diabetes (UPDATE)

As reported in Medscape, new case studies from Canada support the findings of the UK research.(3/4)

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The results of a clinical trial in UK, just announced, are that as many as half of diabetics can be “cured” (achieve remission of the disease) though weight loss within 6 years of diagnosis. The result is achieved through improved performance of pancreatic beta cells.

This is the ultimate in medical findings: we have a problem, a process for curing the problem, and a method that explains how and why the process works. That’s a very strong and tidy package.

Functioning of the liver and pancreas is improved by reducing fat content in those organs, as shown in the images below.

And it explains why people can achieve diabetes remission through the IF816 diet, as noted in a prior post.

This observation carries potentially important implications for the initial clinical approach to management,” says senior study author Roy Taylor of Newcastle University. “At present, the early management of type 2 diabetes tends to involve a period of adjusting to the diagnosis plus pharmacotherapy with lifestyle changes, which in practice are modest. Our data suggest that substantial weight loss at the time of diagnosis is appropriate to rescue the beta cells.” (1)

Bottom line, many people can avoid needing insulin simply by losing weight.


sources:

  1. Roy Taylor, Ahmad Al-Mrabeh, Sviatlana Zhyzhneuskaya, Carl Peters, Alison C. Barnes, Benjamin S. Aribisala, Kieren G. Hollingsworth, John C. Mathers, Naveed Sattar, Michael E.J. Lean. Remission of Human Type 2 Diabetes Requires Decrease in Liver and Pancreas Fat Content but Is Dependent upon Capacity for β Cell Recovery. Cell Metabolism, 2018; DOI: 10.1016/j.cmet.2018.07.003
  2. Cell Press. “Why weight loss produces remission of type 2 diabetes in some patients.” ScienceDaily. ScienceDaily, 2 August 2018. <www.sciencedaily.com/releases/2018/08/180802141722.htm>.
  3. https://www.medscape.com/viewarticle/903204?nlid=125525_1521&src=WNL_mdplsfeat_181016_mscpedit_wir&uac=153634BV&spon=17&impID=1771030&faf=1. For full report, see (4) below.
  4. Suleiman Furmli, et. al., “Therapeutic use of intermittent fasting for people with type 2 diabetes as an alternative to insulin,” http://casereports.bmj.com/content/2018/bcr-2017-221854.full. Published 9 October 2018.
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